Current Opinion in Biomedical Engineering provides systematic and focused reviews of the latest developments in different areas of the field of biomedical engineering. The Journal editors invite experts to evaluate the most innovative and interdisciplinary advances published in the previous 3-5 years. In addition to describing recent trends, authors will provide their subjective opinion on the topics discussed.
Each issue will review two of the major themes of biomedical engineering outlined below. In doing so, the Journal will serve as an invaluable resource to help bridge knowledge gaps amongst the researchers, academics, clinicians, professionals, and students with specializations in the various sub-disciplines of this field.
- Biomechanics and mechanobiology
- Biomedical imaging
- Future of biomedical engineering
- Molecular and cellular engineering
- Neural engineering
- Novel biomedical technologies
- Tissue engineering and regenerative medicine
Selection of the topics to be reviewed:
Section Editors, who are major authorities in the field, are appointed by the Editor-in-Chief of the journal. They divide their section into a number of topics representing key subfields of the discipline, ensuring that the field is comprehensively covered and that all issues of current importance are emphasized. Section Editors, together with specialist Guest Editors, commission reviews from authorities on each topic that they have selected with the aim to stimulate exchange of ideas amongst experts. Editorial Board members are experts in the various subfields of the discipline, and support the Section Editors in the identification of important topical areas, Guest Editors, and prospective authors.
Invited review articles:
Authors write short review articles (about 2500 words or 5-10 printed pages with figures) in which they present most recent developments in their subject, emphasizing the aspects that, in their opinion, are most important. In addition, they provide short annotations to the papers that they consider to be most interesting from all those published in their topic over the previous three to four years. The review articles undergo internal review by the Guest Editors, Section Editors and Editorial Board members.
Section Editors, together with the Guest Editors, will write a short overview at the beginning of the section to introduce the reviews and to draw the reader's attention to any particularly interesting developments.
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Free download research paperA. Pathak and S. Kumar (2011). Biophysical regulation of tumor cell invasion: Moving beyond matrix stiffness. Integrative Biology 3: 267-278 (PDF). A. Pathak and S. Kumar (2011). From molecular signal activation to locomotion: An integrated, multiscale analysis of cell motility on defined matrices. PLoS ONE 6: E18423 (PDF). S. Sen, W. P. Ng, and S. Kumar (2011). Contractility dominates adhesive ligand density in regulating cellular de-adhesion and retraction kinetics. Annals of Biomedical Engineering 39: 1163-1173 (PDF). J. Lee, B. H. Chu, S. Sen, A. Gupte, T. J. Chancellor, C.-Y. Chang, F. Ren, S. Kumar, and T. P. Lele (2011). Modulating malignant epithelial tumor cell adhesion, migration, and mechanics with nanorod surfaces. Biomedical Microdevices 13: 89-95 (PDF). 2010 K. Tanner, A. Boudreau, M. J. Bissell, and S. Kumar (2010). Dissecting regional variations in stress fiber mechanics in living cells with laser nanosurgery. Biophysical Journal 99: 2775-2783 (PDF). A. J. Keung, S. Kumar, and D. V. Schaffer (2010). Presentation counts: Microenvironmental regulation of stem cells by biophysical and material cues. Annual Review of Cell and Developmental Biology 26: 533-556 (PDF). B. Ananthanarayanan and S. Kumar (2010). Cell mechanobiology in regenerative medicine: Lessons from cancer. Book chapter for the CRC Biomedical Engineering Handbook, CRC Press-Taylor and Francis Group, LLC (scheduled for publication in 2011). S. Kumar (2010). Cell-extracellular matrix mechanobiology in cancer. Chapter for Comprehensive Biophysics, Elsevier (scheduled to appear online in 2011). A. J. Keung, K. E. Healy, S. Kumar, and D. V. Schaffer (2009). Biophysics and dynamics of natural and engineered stem cell microenvironments. Wiley Interdisciplinary Reviews (WIREs): Systems Biology and Medicine 2: 49-64 (PDF). W. A. Lam, L. Cao, V. Umesh, A. J. Keung, S. Sen, and S. Kumar (2010). Extracellular matrix rigidity modulates neuroblastoma cell differentiation and N-Myc expression. Molecular Cancer 9: 35 (PDF). A. Patel, R. G. Thakar, M. Chown, P. Ayala, T. A. Desai, and S. Kumar (2010). Biophysical Mechanisms of Single-Cell Interactions with Microtopographical Cues. Biomedical Microdevices 12: 287-296 (PDF). T. A. Ulrich, A. Jain, K. Tanner, J. L. MacKay, S. Kumar (2010). Probing cellular mechanobiology in three-dimensional culture with collagen-agarose matrices. Biomaterials 31: 1875-1884 (PDF). T. A. Ulrich and S. Kumar (2011). Mechanobiology in health and disease in the central nervous system. Book chapter for Mechanobiology Handbook, CRC Press-Taylor and Francis Group, LLC. S. Sen and S. Kumar (2010). Combining mechanical and optical approaches to dissect cellular mechanobiology. Journal of Biomechanics 43: 45-54 (PDF). 2009 S. Sen, M. Dong, and S. Kumar (2009). Isoform-specific contributions of α-actinin to glioma cell mechanobiology. PLoS ONE 4: E8427 (PDF). S. Kumar, P. Parot, J. L. Pellequer (2009). Second international AFM Biomed conference on AFM in the life sciences and medicine, 16-18 October 2008, Monterey, CA, USA [editorial]. Journal of Molecular Recognition 22: 345-346. (PDF) D. J. D Sa, E. M. de Juan Pardo, R. de las Rivas Astiz, S. Sen, and S. Kumar (2009). High-throughput indentational elasticity measurements of hydrogel extracellular matrix substrates. Applied Physics Letters 95:63701 1-3 (PDF). S. Sen and S. Kumar (2009). Cell-matrix de-adhesion dynamics reflect contractile mechanics. Cellular and Molecular Bioengineering 2: 218-230. (PDF). T. A. Ulrich, E. M. de Juan Pardo, and S. Kumar (2009). The mechanical rigidity of the extracellular matrix regulates the structure, motility, and proliferation of glioma cells. Cancer Research 69: 4167-4174. (PDF). S. Kumar and V. M. Weaver (2009). Mechanics, malignancy, and metastasis: The force journey of a tumor cell. Cancer and Metastasis Reviews 28:113-127. (PDF) 2008 Luo, Y., Xu, X., Lele, T., Kumar, S., and Ingber, D.E. (2008). A multi-modular tensegrity model of an actin stress fiber. Journal of Biomechanics 41: 2379-2387. (PDF) R. G. Thakar, M. G. Chown, A. Patel, L. Peng, S. Kumar, and T. A . Desai (2008). Contractility-dependent modulation of cell proliferation and adhesion by microtopographical cues. Small 4: 1416-1424. (PDF) R. J. Mannix*, S. Kumar*, F. Cassiola, M. Montoya-Zavala, E. Feinstein, M. Prentiss, and D. E. Ingber (2008). Nanomagnetic actuation of receptor-mediated signal transduction. Nature Nanotechnology 3: 36-40 [*equal contribution]. (PDF) (Nature Nanotechnology Highlight) 2007 M. Chown and S. Kumar (2007). Imaging and manipulating the structural machinery of living cells on the micro- and nanoscale. International Journal of Nanomedicine 2: 333-344 (PDF) . T. P. Lele, J. Sero, B. Matthews, S. Kumar, N. Xia, M. Montoya-Zavala, T. Polte, D. R. Overby, N. Wang, and D. E. Ingber (2007). Tools to study cell mechanics and mechanotransduction. In Cell Mechanics (Academic Press, Y.-L. Wang and D. E. Discher, Eds.) Methods in Cell Biology 83: 435-464. (PDF) T. P. Lele and S. Kumar (2007). Brushes, cables, and anchors: Recent insights into multiscale assembly and mechanics of cellular structural networks. Cell Biochemistry and Biophysics 47: 348-360 (PDF). 2006 C. P. Brangwynne, F. C. MacKintosh, S. Kumar, N. A. Geisse, J. Talbot, L. Mahadevan, K. K. Parker, D. E. Ingber, and D. A. Weitz (2006). Microtubules can bear enhanced compressive loads in living cells because of lateral reinforcement. Journal of Cell Biology 173: 733-741. (PDF) (JCB Highlight) (Current Biology Dispatch) S. Kumar, I.Z. Maxwell, A. Heisterkamp, T.R. Polte, T.P. Lele, M. Salanga, E. Mazur, and D.E. Ingber (2006). Viscoelastic retraction of single living stress fibers and its impact on cell shape, cytoskeletal organization and extracellular matrix mechanics. Biophysical Journal 90: 3762-3773. (PDF) T. P. Lele, J. Pendse, S. Kumar, M. Salanga, J. Karavitis, and D. E. Ingber (2006). Mechanical forces alter zyxin unbinding kinetics within focal adhesions of living cells. Journal of Cellular Physiology 207: 187-194. (PDF) 2005 A. Heisterkamp, I. Z. Maxwell, E. Mazur, J. M. Underwood, J. A. Nickerson, S. Kumar, and D. E. Ingber (2005). Pulse energy-dependence of subcellular ablation by femtosecond laser pulses. Optics Express 13: 3690-3696. (PDF) 2004 and earlier S. Kumar and J. H. Hoh (2004). Modulation of repulsive forces between neurofilaments by sidearm phosphorylation. Biochemical and Biophysical Research Communications 324: 489-496. (PDF) R. Mukhopadhyay, S. Kumar, and J. H. Hoh (2004). Molecular mechanisms for organizing the neuronal cytoskeleton. BioEssays 26: 1017-1025. (PDF) S. Kumar, X. Yin, B. D. Trapp, M. E. Paulaitis, and J. H. Hoh (2002). Role of long-range repulsive forces in organizing axonal neurofilament distributions: Evidence from mice deficient in myelin-associated glycoprotein. Journal of Neuroscience Research 68: 681-690. (PDF) J. Schneider, P. Berndt, K. Haverstick, S. Kumar, S. Chiruvolu, and M. Tirrell (2002). Surface force measurements of electrostatic and hydrogen-bonding interactions between bilayers of glycine amphiphiles. Langmuir 18: 3923-3931. (PDF) S. Kumar, X. Yin, B. D. Trapp, J. H. Hoh, and M. E. Paulaitis (2002). Relating interactions between neurofilaments to the structure of axonal neurofilament distributions through polymer brush models. Biophysical Journal 82: 2360-2372. (PDF) S. Kumar and J. H. Hoh (2001). Probing the machinery of intracellular trafficking with the atomic force microscope. Traffic 2: 746-756. (PDF) S. Kumar and J. H. Hoh (2000). Direct visualization of vesicle-bilayer complexes by atomic force microscopy. Langmuir 16: 9936-9940. (PDF) J. Schneider, P. Berndt, K. Haverstick, S. Kumar, S. Chiruvolu, and M. Tirrell (1998). Force and adhesion measurements between hydrogen-bonded layers of glycine-functionalized amphiphiles. Journal of the American Chemical Society 120: 3508-3509. (PDF)
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